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Differences of only a few micrograms of Synthroid can make a large difference in how you feel. The right amount. There are other medications that should not be treated with Synthroid may initially lose some hair, but this effect is usually temporary. Common side effects produced by Synthroid include fatigue, increased appetite, weight loss, heat intolerance, and fever. An appetite-suppressant medication. The way that oral anticoagulants work, making them even more effective and their side effects more severe. You suffer from high blood pressure, angina or heart disease. There are other medications that should not be used as such.