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Diuretics cause your kidneys to produce more urine, you may prefer to take this medicine in the morning with breakfast or twice a day with breakfast and lunch. As a tablet to take by mouth. This medicine affects you and you are sure you can perform such activities safely. Spironolactone is used in the treatment of a condition called Conn's syndrome, in which there is excess production of Aldosterone by the adrenal glands. Aldactone usually is taken once a day in the morning rather than before going to bed, as this will reduce the likelihood of you needing to get up in the night to visit the toilet. Spironolactone is used in the treatment of a condition called Conn's syndrome, in which there is excess production of Aldosterone by the adrenal glands. When driving or operating machinery until you know how this medicine affects you and you are sure you can perform such activities safely. When driving or operating machinery until you know how this medicine affects you and you are sure you can perform such activities safely. There are many conditions that can lead to an accumulation of fluid in the body.